SCIENTISTS STILL DON'T KNOW what actually causes aging. Maybe it’s that your cells stop dividing, or that your telomeres shorten, or that you exhaust your stem cells, or that your DNA becomes damaged and stops repairing itself, or a combination of all those processes. Or maybe it’s none of them. All we can do to live longer and better for now is treat aging’s symptoms. So that’s what the anti-aging community until this point has been stuck with trying to do.


Articles worth to read


Is Human Life Extension Possible? - Longevity Advice


You might live to be 150 years old.

In fact, if some scientists are to be believed, you might live to be a good deal older even than that.

Sounds crazy right? Like some wild fantasy birthed in the fevered brain of a modern-day Ponce de León?

Perhaps.


The team found genetic variances that are common in the older group who lived past 105 years old. The most common is the STK17A gene, which is responsible for the efficient repair of DNA. High activity of this gene means that it helps combat the growth of diseases like cancer.

Moreover, they also found the presence of BLVRA in the same group. This gene is responsible for the health of a cell.

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PEARL: PARTICIPATORY EVALUATION OF AGING WITH RAPAMYCIN FOR LONGEVITY


The medicine Rapamycin has been shown to extend the healthspan of all organisms it has been tested on – mice, worms, yeast – for decades, and yet to date there has been no trial to sufficiently demonstrate safety and proper dosing for this purpose in humans. It is now time for this to change.


Participatory Evaluation of Aging w/ Rapamycin for Longevity (lifespan.io)



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Scientists to Improve "Longevity Gene" Efficiency in Battling the Aging Process


The team, spearheaded by biology professors Vera Girbunova and Andrei Seluanov, joined by Dirk Bohmann. a professor of biomedical genetics and a number of students and postdoctoral researchers have recently published their new paper that discusses the gene sirtuin 6 (SIRT6). A nickname given to SIRT6 is the "Longevity gene" because of the gene's role in organizing proteins and recruiting enzymes in repairing broken DNA.

In the paper, the team describes SIRT6 as the gene responsible for more efficient DNA repair especially for species with a longer lifespan. The scientists explained that the paper has a goal to improve anti-aging interventions and help prevent diseases that are age-related.

Scientists to Improve "Longevity Gene" Efficiency in Battling the Aging Process | Science Times

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Longevity Study Shows People Over 105 Years Old Have More Efficient DNA Repair



The team found genetic variances that are common in the older group who lived past 105 years old. The most common is the STK17A gene, which is responsible for the efficient repair of DNA. High activity of this gene means that it helps combat the growth of diseases like cancer.

Moreover, they also found the presence of BLVRA in the same group. This gene is responsible for the health of a cell.

Longevity Study Shows People Over 105 Years Old Have More Efficient DNA Repair | Science Times

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Longevity Herbs & Kundalini Herbs (xs4all.nl)

DNA Methylation to determine biological age | The Knowledge Society (tks.world)

Biological age may slow down by more than three years in just eight weeks through DNA methylation, new research shows. DNA methylation is a biological process by which methyl groups are added to the DNA molecule.


Ageing Slows Down by 3 Years in Just 8 Weeks Through Diet, Lifestyle Changes, DNA Methylation Study Shows | Science Times


Biological Age Tests - Keep Health | Keeping Healthy People Healthy

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NAD+: A Complete Guide To This Longevity-Boosting Coenzyme


Longevity - Elixir of St. Germain (innergarden.org) Ancient Egyptian Longevity herbs


Building Support for the War Against Aging | Lifespan.io


Future Dynasty of Super-Rich Super -Centenarians Good Article In Polish Language


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FROM OTHER PAGE, SIMILAR


Longevity to read (amsil.com) FORMER https://amsil.com/longevityread.html


What are aging cells? By definition, senescent cells are those that have stopped dividing, and their normal physiological function and proliferation have declined Not only that, they also release cytokines that promote inflammation and "spread negative energy" to surrounding cells. Currently, cell aging is considered to be the root cause of many aging-related diseases, including cancer, heart disease, diabetes and dementia. Recent studies have shown that removing aging cells from the brain that have lost their ability to divide can improve symptoms of neurodegenerative diseases and alleviate the cognitive decline associated with aging.

So here's the question: What can be done to easily and effectively remove aging cells? Research teams at the University of Salford's Translational Medicine Laboratory in the UK have discovered that at least one antibiotic can be used.

Sirtuins with DNA repair


Unrepairable DNA damage is thought to be one of the basic causes of cell aging, and a decline in age-related DNA repair can lead to increased damage accumulation, which in turn can lead to cell aging. Sirtuins is essential for DNA repair, inflammation control and antioxidant defenses, making it a good anti-aging target. 

If they are just forbidden masters, we don't want to talk much, but the Sirtuins family's protein has another name: longevity protein. Many of the so-called "god medicines" that we know well need to rely on this family to exert their power! Today we'll take a look at what kind of big family the Sirtuins protein family is!

Unexpected anti-aging drugs: How can this common molecule kill aging cells? - Know (zhihu.com)

Speech | reduce old age weakness by 50%! Is AKG, the natural anti-decay molecule beloved by brain Kennedy, the anti-decay scholar, expected to be the next "god drug" for longevity? - Know (zhihu.com)


Rapamycin (also knownIs a rapamycin a miracle drug? Or is it just killing men slowly? as Sirolimus and AY-22989), antifungal and immunosuppressants. is a mTOR (short for mammalian target of rapamycin) protein-specific inhibitor that binds to the intracellular receptor FKBP-12 to form a compound and acts directly on the FRB (FKBP-12-rapamycin binding) domain in mTOR to inhibit protein activity.

M.D. Dr. Sabatini didn’t set out to get mixed up in this odd world of antiaging, but in 1992, peering down at a sample he was analyzing one day as a student at Johns Hopkins Medical School, he discovered a protein, now called mTOR (short for mammalian target of rapamycin), that would eventually form a link between the way rapamycin might extend life and the way caloric restriction does. He had discovered the mTOR cellular-signaling pathway that answers to rapamycin. The drug just might act on the very causes of aging.

Dr. Sabatini, now a professor of biology at the Whitehead Institute and MIT, explains the mTOR pathway like this: Pretend your body is an old house. Your oldest cells have all sorts of problems and are implicated in your house falling apart. “You couldn’t fully renovate the old house by bringing in only a plumber, or only an electrician, or a roofer, or a drywall guy,” says Dr. Sabatini. “You’d need to hire a general contractor, who would hire all those specialists who would then come fix all those problems that needed to be fixed.” The mTOR pathway is like the general contractor, signaling to your body to demolish parts of its old cells and replace them with newer, healthier ones.

Dr. Sabatini thinks rapamycin essentially tricks the body into thinking that it’s in a state of calorie deprivation, which is what causes the contractor to call in all the guys for renovation work. The cellular workers consume your oldest, weakest cell parts, even parts of senescent cells. These are cells that no longer divide and are thought to spur aging and maybe even drive cancer. Which is to say that rapamycin could give you all the benefits of fasting without the ravenous downsides. In addition to the studies on rapamycin in yeast, worms, flies, and mice, in 2014 scientists began work on dogs; it found that those on the drug showed signs of younger hearts and a reversal of age-related cardiac issues.

While this was going on, Mikhail Blagosklonny, Ph.D., M.D., a prolific researcher on aging at the Roswell Park Comprehensive Cancer Center in Buffalo, began writing about his theories on rapamycin in medical journals. He noted its antiaging promise in 2008 and hypothesized that a lower dose than transplant patients take might bring on benefits without side effects. On Christmas Eve in 2014, a study conducted by researchers at Novartis and Stanford and published in Science Translational Medicine confirmed Dr. Blagosklonny’s theory. Older people taking the drug for six weeks didn’t see their immunity decrease—it actually increased in groups that took as little as 0.5mg a day or 5mg a week. Adult transplant patients typically take a 2mg dose every day.

The drug is already generic, drug companies aren’t interested, and anti-aging enthusiasts are going ahead and taking it, sometimes with severe consequences.

Charles found a post with a link to an obscure, unregulated pharmacy in India that was willing to ship anyone rapamycin, no prescription needed. Louis got his from a supplier he won’t disclose.

Van located the one doctor in the U.S. who would prescribe the drug. His name is Alan Green, M.D., and he treats patients out of his home in Bayside, Queens. Because you have to visit him in person, Van flew to LaGuardia Airport, took a cab to Bayside, and wound up in Dr. Green’s office. Van filled the Rx, dumped six of the aspirin-sized 1mg pills into his hand, and popped them into his mouth. He flew back to Boston, and at home he’d take that same 6mg dose once weekly. “My blood work quickly became that of someone 20 to 30 years younger,” he says.

Source:

The Risky Anti-Aging Pill Men Are Taking Now - Rapamycin (menshealth.com)


Other "Longevity" Drinks

146 years old men

Geneticists Discover a Way to Extend Lifespans to 800 Years

The man who lived for 800 years

What would it be like to live for 800 years? As far as I know, only a few historical characters could know about that. A man named Peng Zu was among them. What was his secret?


NAD+ and Sirtuins in Aging/Longevity Control

Sirtuins (Sirt) are a family of histone deacetylases that have been shown to regulate organism al lifespan as well as oxidative stress and DNA damages

Sirtuin - an overview | ScienceDirect Topics

Abstract

Mitochondrial sirtuins (SIRT3–5) are part of the sirtuin family of NAD+ dependent deacylases and ADP ribosyl transferases. While mitochondrial sirtuins have been the focus of research for the last decades, many aspects of sirtuin biology remain unknown. Together with the other members of the sirtuin family, the activity of mitochondrial sirtuins is dependent on NAD+, which couples the nutrient status of the cell with coordinated stress responses. Mitochondrial sirtuin activity has been implicated in aging and the development of numerous diseases including cancer, neurodegeneration and insulin resistance. In this chapter, we will discuss the different functions and regulation of the mitochondrial sirtuins under stress conditions. We will highlight the aspects of sirtuin biology that are currently unknown and deserve additional research. In addition, we will discuss the function of mitochondrial sirtuins in the development of numerous pathologies.


First Randomized, Double-blind, Placebo Controlled Study To Show Telomeres Getting Longer In Humans


© Research | First Randomized Double-Blind Placebo Controlled Study
Source: 
https://www.tasciences.com/longer-telomeres-study.html


TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 97 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period, as compared to the placebo group (530 ± 180 bp; p = 0.005), whereas subjects in the placebo group significantly lost TL (290 ± 100 bp; p = 0.01). The high dose of TA-65 (1000 U) showed a trend of improvements in TL compared with that of the placebo group; however, the improvements did not reach statistical significance. TL changes in the low-dose group were similar for both median and 20th percentile TLs. The findings suggest that TA-65 can lengthen telomeres in a statistically and possibly clinically significant manner.

Study Summary

As expected, the placebo group showed a decrease in telomere length

Placebo Group
Decrease in median telomere length over 12 months

Median telomere length

 290 ± 100 bp

20th percentile telomere length

 170 ± 50 bp

While the group taking one capsule of TA-65® (250 Units) per day showed an increase in telomere length

TA-65® Group
Increase vs placebo group in median telomere length over 12 months

Median telomere length

 533 ± 180 bp

20th percentile telomere length

 270 ± 90 bp


SUPERIOR CHINESE MEDICINE

Quality: Amsil uses only the  highest grade herbs in its production. Chinese herbal remedies, typically, do not lose potency for five years or more. However, our Chinese medicine formulas are fresh out of manufacturing thus ensuring that the herbal ingredients are the most potent, as possible. All Chinese herbs are GMP certified. All formulas are re-checked for complete natural purity by chemists and the senior master herbalist. Our herbal business maintains those standards everyday, year after year.

We strive to make our products and services more economical while not sacrificing herb quality and superior effect. We provide higher grade of herbs. Thus results, are commonly attained by our clients.



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The Grand-masters of Traditional ChinesE Medicine (TCM) used and observed the effects of their formulas for over 2,000 years. By virtue of their quality, TCM formulas have survived the test of time. When properly prepared and applied, they help to build healthy bodies, prolong life and eliminate imbalances. TAM has remained hidden from the Western world… until now.

We are committed to provide an education in the use of these formulas, extracts, and medicines while offering them at reasonable cost. It is our hope that we can relieve suffering while significantly improving the health and longevity of those we serve.

We urge you to make full use of the information which we provide in full cooperation with the advice and recommendations of your physician, nurse, herbalist, chiropractor, naturopath (ND), acupuncturist, or other health care professional.

Information provided on this web site is for educational purposes only, is accurate, truthful, and not misleading. Claims are supported by the experience and research of the practice of Traditional Asian Medical practitioners and Doctors in Taiwan, the Peoples Republic of China, Japan, Korea, and by modern Western medical research.



Longevity in qing

It may surprise you, but qigong routines are thought to not only improve health and cure diseases, but to extend the life span. In a way, this logically follows from the idea of qigong, since if people can continuously cure their diseases or bodily injuries by qigong, they’ll not die.

Most Daoist believers believe that there are many people in China who are actually hundreds of years old through the practice of qigong or by taking a special herb or medicine. They worship these people and consider them deities. They are called immortals.



Longevity Wine Recipes

1.The invention relates to longevity wine, which is characterized in that: the longevity wine is prepared by immersing the following medicinal raw materials by mass: 3 to 25g of ginseng, 3 to 20g of folium epimedii, 3 to 20g of spina date seed, 3 to 20g of hairy antler, 2 to 20g of thinleaf milkwort root-bark, 3 to 25g of tortoise plastron, 3 to 20g of turtle shell, 2 to 20g of Indian buead, 2 to 20g of villous amomum fruit, 3 to 30g of cornus fruit, 3 to 30g of astragalus, 3 to 30g of medicinal indianmulberry root, 3 to 30g of hawthorn fruit, 2 to 20g of cooked radix rehmanniae, 3 to 30g of south dodder seed, 2 to 20g of szechuan lovage rhizome, 2 to 20g of Chinese angelica, 3 to 30g of glossy privet fruit, 5 to 20g of whit peony root, 3 to 30g of medlar, 1 to 10g of safflower, 3 to 30g of songaria cynomorium herb, 3 to 30g of mulberry fruit, 3 to 30g of glossy ganoderma, 3 to 30g of desertliving cistanche, 3 to 10g of pseudoginseng root, 2 to 30g of dendrobium, 3 to 25g of tuber fleeceflower root, 3 to 50g of drie

2. The longevity medicated wine and its manufacture method, which uses 60 - 65 Deg. C pure valley white liquor, adding furl seal's kidney, deer's muscle, the winter Chinese caterpillar fungus, the melinda officinalis, Beiqi, Tianma, the seahorse, the gecko and so on 75 kinds of Chinese native medicines raw material for soaking, latter adds the white sugar and the tap water configuration. This invention medicated wine enhances men's and women's sexual dive energy, strengthens the human body vigor for mainly, makes up cloudyly and fortifies female, the synthesis recuperates the human body vital organs of the human body, expels sickness and builds up strength, thus achieves the benefit goal which prolongs the life. Its manufacture method is simple, the medicated wine soaking output contains Chinese native medicine ingredient content which obtains is high, the medicated wine palatableness is good, the feeling in the mouth is pure, preserves long. Long-time drinking can nourish the human body.

3.he invention discloses a Chinese medicine, in particular to a longevous medicinal wine and the preparation method. The invention is characterized in that the longevous medicinal wine comprises the following Chinese medicinal herbs and auxiliary materials by weight: wherein, the Chinese medicinal herb comprises 120 to 180g of sealwort, 130 to 200g of eclipta alba, 200 to 300g of radix-polygoni multiflori, 80 to 120g of fructus ligustri lucidi, 100 to 130g of medlar, 40 to 60g of barrenworts, 50 to 80g of ganoderma lucidum, 60 to 90g of ginseng, 100to 120g of polygala; and the auxiliary materials comprises 12 to 15 kg of Kaoliang spirit which is more than 50 degree, 1000 to 1200g of crystal sugar, 1000 to 1500g of honey and 500 to 750g of denucleated round red date. The invention has high efficiency but no side effect and hormone, and has the effects of nourishing healthy atmosphere, driving out evil spirits, curing the outside and the inside, strengthening kidney-Yang, tonifying yin, promoting blood circulation.



Method of Obtaining Hemp Plant Juice and Use of Same for the Production of Beverages

United States Patent Application 20140044807

The present invention relates to a method for producing beverages on the basis of juice from the hemp plant. The invention relates to a method for obtaining juice suitable for human consumption from the hemp plant, wherein the complete hemp stem is pressed after harvest without prior drying or retting. The invention further provides a method for obtaining juice from the hemp plant, wherein the upper leafy part of the hemp plant is cut, the leaves are stripped of the remaining stem, fibres and shives being separated from each other at the stem, the leafy part of the stem, the fibres and the shives being pressed individually under pressure and the so obtained pressed juices are being mixed in a controlled manner. In a yet further aspect, the invention relates to a method for the manufacturing of beverages on the basis of juice from the hemp plant, wherein the hemp juice is mixed with yeast and than fermented.



Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review


Abstract

Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during thousands of years of practice; modern pharmacological studies have confirmed the therapeutic effects of many active components derived from Chinese herbal medicines (CHM). Ginsenoside Rg1, extracted from Radix Ginseng, exerts a [Formula: see text]-secretase inhibitor effect so as to decrease A[Formula: see text] aggregation. It can also inhibit the apoptosis of neuron cells. Tanshinone IIA, extracted from Radix Salviae miltiorrhizae, and baicalin, extracted from Radix Scutellariae[Formula: see text] can inhibit the oxidative stress injury in neuronal cells. Icariin, extracted from Epimedium brevicornum, can decrease A[Formula: see text] levels and the hyperphosphorylation of tau protein, and can also inhibit oxidative stress and apoptosis. Huperzine A, extracted from Huperzia serrata, exerts a cholinesterase inhibitor effect. Evodiamine, extracted from Fructus Evodiae, and curcumin, extracted from Rhizoma Curcumae Longae, exert anti-inflammatory actions. Curcumin can act on A[Formula: see text] and tau too. Due to the advantages of multi-target effects and fewer side effects, Chinese medicine is more appropriate for long-term use. In this present review, the pharmacological effects of commonly used active components derived from Chinese herbal medicines in the treatment of AD are discussed.

source:

Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review - PubMed (nih.gov)



Brain Food for Alzheimer-Free Aging: Focus on Herbal Medicines

Healthy brain aging and the problems of dementia and Alzheimer’s disease (AD) are a global concern. Beyond 60 years of age, most, if not everyone, will experience a decline in cognitive skills, memory capacity and changes in brain structure. Longevity eventually leads to an accumulation of amyloid plaques and/or tau tangles, including some vascular dementia damage. Therefore, lifestyle choices are paramount to leading either a brain-derived or a brain-deprived life. The focus of this review is to critically examine the evidence, impact, influence and mechanisms of natural products as chemopreventive agents which induce therapeutic outcomes that modulate the aggregation process of beta-amyloid (Aβ), providing measureable cognitive benefits in the aging process. Plants can be considered as chemical factories that manufacture huge numbers of diverse bioactive substances, many of which have the potential to provide substantial neuroprotective benefits. Medicinal herbs and health food supplements have been widely used in Asia since over 2,000 years. The phytochemicals utilized in traditional Chinese medicine have demonstrated safety profiles for human consumption. Many herbs with anti-amyloidogenic activity, including those containing polyphenolic constituents such as green tea, turmeric,Salvia miltiorrhiza, andPanax ginseng, are presented. Also covered in this review are extracts from kitchen spices including cinnamon, ginger, rosemary, sage, salvia herbs, Chinese celery and many others some of which are commonly used in herbal combinations and represent highly promising therapeutic natural compounds against AD. A number of clinical trials conducted on herbs to counter dementia and AD are discussed. 
Abstract

source: 
 Brain Food for Alzheimer-Free Ageing: Focus on Herbal Medicines - PubMed (nih.gov)


The Ancient wisdom of Chinese Tonic Herbs


Abstract

If someone told you how to slow ageing, gain unlimited energy, sharpen your mental clarity, have great-looking skin, reduce stress and look and feel younger, most people would want to know more. The answer feels like the best kept secret, but it's really not. It's practiced by millions of people in China; it's just a secret to the rest of the world. The secret is the magic of Chinese tonic herbs. The art of radiant health has been widely practiced for thousands of years by the people of the East. In China, this healthcare art is practiced through the consumption of tonic teas and super herbs. Chinese tonic herbs make a major contribution toward one's ultimate well-being by providing special nutrients that help the body and mind become radiantly healthy, through the consumption of nutrients that are not available in our daily food source. Among the richest source of antioxidants, when consumed over a period of time, these herbs can profoundly enhance the performance of our bodies and minds and help us achieve radiant health and longevity. With these herbs in the diet, the immune system flourishes.

The ancient wisdom of Chinese tonic herbs | Professional Beauty (informit.org)




Human Longevity San Diego ¨C La Jolla, California


Human Longevity, Inc. (HLI) is the genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived. HLI combines the largest database of genomic and phenotypic data with machine learning to drive discoveries and revolutionize the practice of medicine. HLI’s business areas include the HLI Health Nucleus, a genomic powered clinical research center which uses whole genome sequence analysis, advanced clinical imaging and innovative machine learning, along with curated personal health information, to deliver the most complete picture of individual health; HLIQ™ Whole Genome and HLIQ Oncology.




Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework


AbstracT

Human longevity is a complex trait, and to disentangle its basis has a great theoretical and practical consequences for bio-medicine. The genetics of human longevity is still poorly understood despite several investigations that used different strategies and protocols. Here, we argue that such rather disappointing harvest is largely because of the extraordinary complexity of the longevity phenotype in humans. The capability to reach the extreme decades of human lifespan seems to be the result of an intriguing mixture of gene-environment interactions. Accordingly, the genetics of human longevity is here described as a highly context-dependent phenomenon, within a new integrated, ecological, and evolutionary perspective, and is presented as a dynamic process, both historically and individually. The available literature has been scrutinized within this perspective, paying particular attention to factors (sex, individual biography, family, population ancestry, social structure, economic status, and education, among others) that have been relatively neglected. The strength and limitations of the most powerful and used tools, such as genome-wide association study and whole-genome sequencing, have been discussed, focusing on prominently emerged genes and regions, such as apolipoprotein E, Forkhead box O3, interleukin 6, insulin-like growth factor-1, chromosome 9p21, 5q33.3, and somatic mutations among others. The major results of this approach suggest that the genetics of longevity is highly population specific; small-effect alleles, pleiotropy, and the complex allele timing likely play a major role; genetic risk factors are age specific and need to be integrated in the light of the geroscience perspective; a close relationship between genetics of longevity and genetics of age-related diseases (especially cardiovascular diseases) do exist. Finally, the urgent need of a global approach to the largely unexplored interactions between the 3 genetics of human body, that is, nuclear, mitochondrial, and microbiomes, is stressed. We surmise that the comprehensive approach here presented will help in increasing the above-mentioned harvest.

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework - PubMed (nih.gov)

How we can extend health and longevity beyond 100 (xprize.org)



Herbal Supplement Disclaimer

These statements have not been evaluated by the FDA. This product is a dietary supplement and is not intended to diagnose, cure, prevent or treat any diseases. The information here is not provided by medical (allopathic) professionals and is not intended as a substitute for medical advice. Please consult your physician before beginning any course of treatment. However, billions of people have used these products without complication. These herbal formulas have been used in conjunction with conventional medical regimens, successfully. Most important, the key is conducting a Chinese medicine assessment to ensure the correct formula and result.